School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, P. R. China.
Jiangsu Key Laboratory of Advanced Organic Materials, Nanjing University, Nanjing, 210093, P. R. China.
Chemistry. 2018 Nov 22;24(65):17205-17209. doi: 10.1002/chem.201804157. Epub 2018 Oct 24.
An efficient electrochemical 1,2-sulfonylation/alkynylation of alkenes via radical 1,4-alkynyl migration of alkynyl-substituted tertiary alcohols is described, which used sodium sulfinates as sulfonyl sources affording the corresponding α-sulfonyl-β-alkynylated products in moderate to excellent yields. This electrochemical reaction proceeds smoothly without the use of any metal catalyst, additive and oxidant and thus represents a new and eco-friendly strategy for the difunctionalization of unactive olefins, and also the first example of the electrochemical distal radical migration reaction.
一种通过炔基取代的叔醇的自由基 1,4-炔基迁移实现的高效电化学 1,2-磺酰化/炔基化烯烃的方法，其中使用磺酸钠作为磺酰源，以中等至优异的收率得到相应的α-磺酰基-β-炔基化产物。该电化学反应在无需使用任何金属催化剂、添加剂和氧化剂的情况下顺利进行，因此代表了一种用于不活泼烯烃双官能化的新的环保策略，也是电化学远程自由基迁移反应的首例实例。
