重度抑郁症大脑的表观遗传学年龄分析。
Epigenetic age analysis of brain in major depressive disorder.
机构信息
Mental Health Institute of the Second Xiangya Hospital, Central South University, Chinese National Clinical Research Center on Mental Disorders (Xiangya), Chinese National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan 410011, China; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Mental Health Institute of the Second Xiangya Hospital, Central South University, Chinese National Clinical Research Center on Mental Disorders (Xiangya), Chinese National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan 410011, China.
出版信息
Psychiatry Res. 2018 Nov;269:621-624. doi: 10.1016/j.psychres.2018.09.001. Epub 2018 Sep 6.
A large body of evidence indicates major depressive disorder (MDD) associated with biological aging acceleration. In this study, we aim to assess epigenetic aging in different prefrontal sub-regions and cell types from postmortem tissues in MDD by using two public methylation datasets (subjects are 40 and 58 respectively). Results showed that brain epigenetic age has a strong correlation with chronological age in both datasets. However, there are no significant differences in epigenetic aging acceleration between MDD and controls in all prefrontal sub-regions and cell types. In conclusion, this study provides evidence against epigenetic aging acceleration in the brain in MDD.
大量证据表明，重度抑郁症（MDD）与生物衰老加速有关。在这项研究中，我们旨在通过使用两个公共甲基化数据集（分别为 40 岁和 58 岁的受试者）评估 MDD 死后组织中不同前额叶亚区和细胞类型的表观遗传衰老。结果表明，两个数据集的脑表观遗传年龄与实际年龄有很强的相关性。然而，在所有前额叶亚区和细胞类型中，MDD 与对照组之间的表观遗传衰老加速没有显著差异。综上所述，本研究为 MDD 中大脑的表观遗传衰老加速提供了证据。
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