Doane Cynthia J, Patil Karuna, Hoffman Emely A, Stokes Jessica, Katsanis Emmanuel, Besselsen David G
University Animal Care, University of Arizona, Tucson, Arizona, USA.
Departments of Pediatrics, University of Arizona, Tucson, Arizona, USA.
Comp Med. 2018 Oct 1;68(5):349-352. doi: 10.30802/AALAS-CM-18-000043. Epub 2018 Sep 12.
Multiple adult female CB6F1 mice presented with supernumerary incisors after preconditioning with chemotherapy and total body irradiation for bone marrow transplantation (BMT). Mice received nonmyeloablative total body irradiation (3 Gy) and either cyclophosphamide or bendamustine, followed by BMT and posttransplantation cyclophosphamide or bendamustine. Here we describe the clinical presentation, μCT findings, and histopathologic evaluation of the affected mice. These analyses confirmed the gross diagnosis and revealed details of the abnormal tooth morphology. We surmise that the combination of total body irradiation and chemotherapy resulted in the abnormal formation of supernumerary incisors. Supernumerary teeth should be considered as a potential confounding factor in tracking weight loss after BMT. These conditions can be managed to allow animals to reach their intended scientific endpoint.
多只成年雌性CB6F1小鼠在接受化疗预处理和全身照射以进行骨髓移植（BMT）后出现了多生牙。小鼠接受了非清髓性全身照射（3 Gy），并给予环磷酰胺或苯达莫司汀，随后进行BMT以及移植后环磷酰胺或苯达莫司汀治疗。在此，我们描述了受影响小鼠的临床表现、显微CT（μCT）结果以及组织病理学评估。这些分析证实了大体诊断，并揭示了异常牙齿形态的细节。我们推测全身照射和化疗的联合导致了多生牙的异常形成。在追踪BMT后体重减轻情况时，多生牙应被视为一个潜在的混杂因素。可以对这些情况进行处理，以使动物达到预期的科学终点。
