炎症、肥胖与 1 型糖尿病青少年动脉僵硬度的进展：SEARCH CVD 研究。
Inflammation, adiposity, and progression of arterial stiffness in adolescents with type 1 diabetes: The SEARCH CVD Study.
机构信息
Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, USA.
Department of Biostatistical Sciences, Wake Forest School of Medicine, USA.
出版信息
J Diabetes Complications. 2018 Nov;32(11):995-999. doi: 10.1016/j.jdiacomp.2018.08.004. Epub 2018 Aug 9.
AIMS
We examined the association between inflammation and progression of arterial stiffness in a population of youth with type 1 diabetes (T1D).
METHODS
A total of 287 youth with T1D (median age 13 years) from SEARCH CVD, an ancillary study to the SEARCH for Diabetes in Youth, were included. Markers of inflammation (CRP, IL-6, fibrinogen, leptin, and adiponectin) and measures of pulse wave velocity (PWV) of the arm (PWV-R), trunk (PWV-T), and lower extremity (PWV-LE) were measured at baseline. Measures of PWV were repeated approximately five years later.
RESULTS
PWV-R (0.50 m/s), PWV-T (0.65 m/s), and PWV-LE (1.0 m/s) significantly increased over the follow-up (p < 0.001 for each). A significant interaction was found between waist circumference and fibrinogen (p = 0.036) on the progression of PWV-T, suggesting that fibrinogen is more strongly associated with PWV progression in lean participants.
CONCLUSIONS
Improved understanding of adiposity, inflammation, and functional changes in the vascular system in patients with T1D is crucial.
目的
我们在患有 1 型糖尿病（T1D）的青年人群中研究了炎症与动脉僵硬度进展之间的关系。
方法
共纳入了来自 SEARCH CVD 的 287 名 T1D 青年患者（中位年龄 13 岁），该研究是 SEARCH for Diabetes in Youth 的一项辅助研究。在基线时测量了炎症标志物（CRP、IL-6、纤维蛋白原、瘦素和脂联素）和臂部脉搏波速度（PWV-R）、躯干（PWV-T）和下肢（PWV-LE）的测量值。大约五年后重复测量 PWV。
结果
PWV-R（0.50m/s）、PWV-T（0.65m/s）和 PWV-LE（1.0m/s）在随访期间显著增加（p<0.001）。在 PWV-T 的进展方面，发现腰围和纤维蛋白原之间存在显著的交互作用（p=0.036），提示在瘦参与者中，纤维蛋白原与 PWV 进展的相关性更强。
结论
在 T1D 患者中，更好地理解肥胖、炎症和血管系统的功能变化至关重要。
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