Kamura T, Tsukamoto N, Jo S, Imachi M, Kaku T, Matsukuma K, Matsuyama T
Gan To Kagaku Ryoho. 1986 Oct;13(10):2954-9.
Thirty previously untreated patients with epithelial ovarian carcinoma were treated with cisplatin and adriamycin (PA). Of eight evaluable patients, six were responders (two CRs and four PRs). The three-year survival rates were 83% for stage I, 67% for stage II, 50% for stage III, and none for stage IV. Toxicities included moderate myelo-suppression, mild nephrotoxicity, alopecia, and severe vomiting in almost all patients. Patients with residual lesions smaller than 2 cm had excellent prognosis when PA was given for more than five courses. Patients with residual lesions larger than 2 cm, however, had poor prognosis irrespective of the number of courses. No specific relation between histological grade and prognosis could be found. From the present data, aggressive cytoreductive surgery followed by PA therapy repeated more than five times is recommended for achieving a good outcome in the treatment of epithelial ovarian carcinoma.
30例既往未接受过治疗的上皮性卵巢癌患者接受了顺铂和阿霉素（PA）治疗。在8例可评估的患者中，6例有反应（2例完全缓解和4例部分缓解）。I期患者的三年生存率为83%，II期为67%，III期为50%，IV期无一例存活。毒性反应包括中度骨髓抑制、轻度肾毒性、脱发，几乎所有患者均有严重呕吐。残留病灶小于2 cm的患者，当给予PA治疗超过5个疗程时预后良好。然而，残留病灶大于2 cm的患者，无论疗程数多少，预后均较差。未发现组织学分级与预后之间有特定关系。根据目前的数据，对于上皮性卵巢癌的治疗，建议在积极的细胞减灭术后重复进行5次以上的PA治疗以获得良好疗效。
