Zhang Wenying, Gong Xiaodi, Wu Qiongwei, Liu Yu, Lao Guoying, Xiao Jinyin, Yang Longtao, Liu Ping, Ma Chengbin
Department of Gynecology, Changning Maternity and Infant Health Hospital, Shanghai, China.
J Invest Surg. 2019 Sep;32(6):560-565. doi: 10.1080/08941939.2018.1483449. Epub 2018 Sep 13.
: To investigate high-risk human papillomavirus (HPV) infection clearance following thin loop electrosurgical excision procedure (t-LEEP) among patients with cervical benign lesion. : This retrospective study analyzed clinical data from patients with cervical benign lesion and HPV infection, who had undergone t-LEEP (T-Group), compared with patients with HPV infection undergone no treatment (NT-Group). Both groups attended regular follow-up between January 2008 and January 2012. Kaplan-Meier analysis was used to compare the HPV clearance time. : The average clearance time was 7.7 months (M) (95% confidence interval [CI]: 6.5-8.9 M) in T-Group, and 10.4 M (95%CI: 9.4-11.3 M) in NT-Group, with significant difference between groups ( = 0.003). Among patients with low viral load, the HPV clearance times were 7.6 M (95%CI: 6.3-9.0 M) in T-Group and 9.7 M (95%CI: 8.6-10.8 M) in NT-Group ( = 0.042). Among patients with high viral load, the HPV clearance times were 8.0 M (95%CI: 5.3-10.6 M) in T-Group and 11.4 M (95%CI: 9.7-13.1 M) in NT-Group ( = 0.041). The average time of HPV clearance in T-Group was shorter than NT-Group in all age groups, with significant differences in ≤29Y-group ( = 0.008) and 30-39Y-group ( = 0.005). The accumulated clearance rate of HPV infection at sixth month and 12th month were 24.5% and 67.9% in T-Group, 7.8% and 43.1% in NT-Group, with significant differences ( = 0.001 at 6th month, = 0.032 at 12th month). : T-LEEP accelerates the clearance of high-risk HPV infection and make the HPV infection rates dropped rapidly in the first year.
探讨宫颈良性病变患者行宫颈环形电切术（t-LEEP）后高危型人乳头瘤病毒（HPV）感染的清除情况。
本回顾性研究分析了2008年1月至2012年1月期间接受t-LEEP的宫颈良性病变合并HPV感染患者（T组）的临床资料，并与未接受治疗的HPV感染患者（NT组）进行比较。两组患者均定期随访。采用Kaplan-Meier分析比较HPV清除时间。
T组HPV平均清除时间为7.7个月（95%置信区间[CI]：6.5-8.9个月），NT组为10.4个月（95%CI：9.4-11.3个月），两组间差异有统计学意义（P=0.003）。病毒载量低的患者中，T组HPV清除时间为7.6个月（95%CI：6.3-9.0个月），NT组为9.7个月（95%CI：8.6-10.8个月）（P=0.042）。病毒载量高的患者中，T组HPV清除时间为8.0个月（95%CI：5.3-10.6个月），NT组为11.4个月（95%CI：9.7-13.1个月）（P=0.041）。T组各年龄组HPV平均清除时间均短于NT组，≤29岁组（P=0.008）和30-39岁组（P=0.005）差异有统计学意义。T组6个月和12个月时HPV感染累积清除率分别为24.5%和67.9%，NT组分别为7.8%和43.1%，差异有统计学意义（6个月时P=0.001，12个月时P=0.032）。
t-LEEP可加速高危型HPV感染的清除，使HPV感染率在第1年迅速下降。
