Pathirana Indunil N, Rajapaksa Chandana, Kawate Noritoshi, Wimalarathne Anuradha, Fonseka Lakshitha, Weerakoon Priyangika Nilmini, Hannan Minhaj A, Alexander Basil, Pushpakumara Anil, Ariyaratne Siril, Tamada Hiromichi
J Zoo Wildl Med. 2018 Sep;49(3):779-783. doi: 10.1638/2018-0019.1.
Two male Asian elephants (bulls 1 and 2) in musth were subcutaneously injected with a long-acting gonadotropin-releasing hormone (GnRH) antagonist, degarelix acetate (240 μg/kg; total dose of 960 mg). Musth behavior (MB) and temporal gland secretions (TGS) were monitored and serum testosterone concentrations were determined. In bull 1, MB and TGS ceased on day 1 and reappeared 5.5 mo after the treatment (day 0). During the subsequent musth cycle, MB and TGS ceased on day 1 and did not appear for 4 mo. In bull 2, MB and TGS ceased at day 7 after the treatment. Musth behavior and TGS recurred on Day 11 and continued for 1 wk, then disappeared for 8 mo. Serum testosterone concentrations decreased ( P < 0.05) in all occasions from day 0 (29.8 ± 15.8 ng/ml; mean ± SEM) to day 1 (2.2 ± 1.1 ng/ml), suggesting a sudden drop in circulating testosterone in musth elephants after the GnRH-antagonist treatment.
对两头处于狂暴期的亚洲雄性大象（公牛1和公牛2）皮下注射长效促性腺激素释放激素（GnRH）拮抗剂醋酸加尼瑞克（240μg/kg；总剂量960mg）。监测狂暴行为（MB）和颞腺分泌（TGS），并测定血清睾酮浓度。在公牛1中，MB和TGS在第1天停止，并在治疗后5.5个月（第0天）再次出现。在随后的狂暴周期中，MB和TGS在第1天停止，4个月未出现。在公牛2中，MB和TGS在治疗后第7天停止。狂暴行为和TGS在第11天复发并持续1周，然后消失8个月。血清睾酮浓度在所有情况下均从第零天（29.8±15.8ng/ml；平均值±标准误）降至第1天（2.2±1.1ng/ml）（P<0.05），表明GnRH拮抗剂治疗后，处于狂暴期的大象循环睾酮突然下降。
