Girotra Tarun, Lowe Forrest, Feng Wuwei
a Department of Neurology , Medical University of South Carolina , Charleston , SC , USA.
Top Stroke Rehabil. 2018 Sep 13:1-7. doi: 10.1080/10749357.2018.1499300.
Pseudobulbar affect (PBA) is a neuropsychological condition of emotional lability and affective dysregulation associated with a variety of neurological conditions such as stroke, traumatic brain disease, and neurodegenerative disease. The true prevalence and medico-social burden of PBA associated with stroke is unclear. Often confused with post-stroke mood disorders, PBA is under-recognized and under-treated.
To provide a comprehensive narrative synthesis of published literature on the topic of PBA.
Literature review was performed by searching the key words "pseudobulbar atrophy", "emotional incontinence," and "stroke" in PubMed. Only manuscripts published in English were appraised and relevant content was extracted, synthesized, and summarized.
A narrative overview was performed on the following topics: epidemiology, pathophysiology, clinical features of differential diagnosis, impact on public health, and therapeutic options.
PBA remains an under-treated condition with significant psychosocial burden on both effected stroke survivors and their families. Advances have been made in developing consensus-based clinical diagnostic criteria for PBA. Early identification and prompt initiation of therapeutic measures are required in these stroke patients. Further research is needed to develop better PBA diagnostic criteria and more cost-effective therapeutic treatment options.
假性球麻痹情感障碍（PBA）是一种与多种神经系统疾病（如中风、创伤性脑疾病和神经退行性疾病）相关的情绪不稳定和情感调节障碍的神经心理学病症。与中风相关的PBA的真实患病率和医学社会负担尚不清楚。PBA常与中风后情绪障碍相混淆，未得到充分认识和治疗。
对已发表的关于PBA主题的文献进行全面的叙述性综述。
通过在PubMed中搜索关键词“假性球麻痹萎缩”、“情感失禁”和“中风”进行文献综述。仅评估以英文发表的手稿，并提取、综合和总结相关内容。
对以下主题进行了叙述性概述：流行病学、病理生理学、鉴别诊断的临床特征、对公共卫生的影响以及治疗选择。
PBA仍然是一种治疗不足的病症，对受影响的中风幸存者及其家庭都有重大的心理社会负担。在制定基于共识的PBA临床诊断标准方面已经取得了进展。这些中风患者需要早期识别并及时启动治疗措施。需要进一步研究以制定更好的PBA诊断标准和更具成本效益的治疗选择。
