Ucar Esra, Eruygur Nuraniye, Atas Mehmet, Ergul Merve, Ergul Mustafa, Sozmen Fazli
Medicinal and Aromatic Plant Department, Vocational School, Cumhuriyet University, 58140, Sivas, Turkey.
Pharmacognosy Department, Faculty of Pharmacy, Selcuk University, 42250, Konya, Turkey.
Cell Mol Biol (Noisy-le-grand). 2018 Aug 30;64(11):13-19.
Plane tree (Platanus orientalis L.) leaves have been employed for centuries in various countries due to their pharmacological value. Therefore, determination of the biological activity of the leaves is of interest. The aim of the study was to evaluate the inhibitory effects against Alzheimer's disease-related enzymes Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE), diabetes mellitus related enzymes α-glucosidase and α-amylase. The antioxidant, anticancer, and antimicrobial activities of the leaves were also studied. According to the results, both water and methanol extracts of P. orientalis demonstrated more α-glucosidase and α-amylase inhibition activity than the antidiabetic drug-acarbose at the same concentration level. In addition, extracts showed good inhibition activity against AChE and BuChE. Significant results were obtained regarding antioxidant, anticancer, and antimicrobial activities. These results are very promising especially for the improvement of pharmaceutical formulations to treat various diseases such as age-related diseases, cancer, diabetes etc. and it is necessary to conduct further experiments.
几个世纪以来，悬铃木（Platanus orientalis L.）的叶子因其药理价值在各国都有应用。因此，测定其叶子的生物活性备受关注。本研究的目的是评估其对与阿尔茨海默病相关的乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BuChE）、与糖尿病相关的α-葡萄糖苷酶和α-淀粉酶的抑制作用。还研究了叶子的抗氧化、抗癌和抗菌活性。结果表明，在相同浓度水平下，悬铃木的水提取物和甲醇提取物对α-葡萄糖苷酶和α-淀粉酶的抑制活性均高于抗糖尿病药物阿卡波糖。此外，提取物对AChE和BuChE也表现出良好的抑制活性。在抗氧化、抗癌和抗菌活性方面也取得了显著成果。这些结果对于改进治疗各种疾病（如与年龄相关的疾病、癌症、糖尿病等）的药物制剂非常有前景，有必要进行进一步的实验。
