肺离子细胞对囊性纤维化中的范式提出挑战。
Pulmonary Ionocytes Challenge the Paradigm in Cystic Fibrosis.
机构信息
Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA; The Pulmonary Center, Boston University School of Medicine, Boston, MA, USA.
Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA; The Pulmonary Center, Boston University School of Medicine, Boston, MA, USA.
出版信息
Trends Pharmacol Sci. 2018 Oct;39(10):852-854. doi: 10.1016/j.tips.2018.08.005. Epub 2018 Sep 10.
Two recent studies have identified novel airway cells termed pulmonary ionocytes that express higher levels of CFTR than other airway cells express. These findings raise new questions in the evolving debate about the physiological role of CFTR in lung epithelia and its importance in the pathogenesis of cystic fibrosis (CF).
最近的两项研究已经鉴定出了新型气道细胞，称为肺离子细胞，这些细胞表达的 CFTR 水平高于其他气道细胞。这些发现为 CFTR 在肺上皮细胞中的生理作用及其在囊性纤维化（CF）发病机制中的重要性这一不断发展的争论提出了新的问题。
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