Institute for Molecular Cardiovascular Research, Rheinisch Westfälische Technische Hochschule Aachen University, Aachen, Germany; Human Genomics Laboratory, University of Medicine and Pharmacy Craiova, Craiova, Romania; Department of Cardiology, Pulmonology, Angiology and Intensive Care, University Hospital, Rheinisch Westfälische Technische Hochschule, Aachen, Germany.
Institute for Molecular Cardiovascular Research, Rheinisch Westfälische Technische Hochschule Aachen University, Aachen, Germany; Human Genomics Laboratory, University of Medicine and Pharmacy Craiova, Craiova, Romania.
Arch Med Res. 2018 Nov;49(8):522-529. doi: 10.1016/j.arcmed.2018.08.008. Epub 2018 Sep 10.
The presence of different APOE isoforms represents a well-known risk factor for cardiovascular diseases. Besides the pleiotropic effects of APOE polymorphism on heart and neurological diseases, this review summarizes the less-known functions of APOE and the possible implications for cardiovascular disorders. Beyond the role as lipid transporting protein, its involvement in lipid membrane homeostasis and signaling, as well as its nuclear transcriptional effects suggests a more complex role of APOE, receiving great interest from researchers and physicians from all medical fields. Due to the presence of different APOE isoforms in human population, understanding APOE's role in pathological processes represents not only a challenge, but a demand for further development of therapeutic strategies for cardiovascular diseases.
不同 APOE 异构体的存在是心血管疾病的一个众所周知的危险因素。除了 APOE 多态性对心脏和神经疾病的多效作用外，本综述还总结了 APOE 不太为人知的功能及其对心血管疾病的可能影响。除了作为脂质转运蛋白的作用外，它还参与脂质膜的动态平衡和信号转导，以及其核转录效应，这表明 APOE 具有更复杂的作用，引起了来自所有医学领域的研究人员和医生的极大兴趣。由于人类群体中存在不同的 APOE 异构体，因此了解 APOE 在病理过程中的作用不仅是一个挑战，也是进一步开发心血管疾病治疗策略的需求。
