Zhou Yun, Liu Shixiong, Wang Jing, Yan Xiang, Zhang Lei
Department of Gerontology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Oncol Lett. 2018 Oct;16(4):4303-4308. doi: 10.3892/ol.2018.9197. Epub 2018 Jul 23.
This study aimed to investigate the changes in blood glucose of elderly patients with gastric cancer combined with type 2 diabetes mellitus (T2DM) after radical operation. Forty-six patients in DM group and 30 patients in non-DM group underwent radical surgery between January, 2007 and January, 2017 in The First Hospital of Lanzhou University, and the clinical data were retrospectively analyzed. Statistical analysis was conducted to explore the effect of radical operation on blood glucose control of the two groups of patients. In 46 patients with gastric cancer combined with T2DM, 24 patients received postoperative insulin intervention, and the remaining 22 patients did not receive insulin intervention. This latter set of patients comprised the non-insulin treatment group. Blood glucose control conditions, inflammatory markers, tumor markers and their effects on the prognosis were compared between the two groups. Level of postoperative blood glucose of the DM group was significantly higher than that of the non-DM group (P<0.05), while the level of blood glucose in the insulin treatment group was significantly lower than that in the control group (P<0.05). Levels of related tumor markers and inflammatory factors of insulin treatment group were significantly higher than those of the control group (P<0.05). The 5-year survival rate of insulin treatment group was significantly higher than that of the control group (P<0.05). Our results showed that the level of blood glucose was significantly increased in elderly patients with gastric cancer combined with T2DM after radical operation, and levels of blood glucose, tumor markers and inflammatory factors in elderly gastric cancer patients with T2DM without insulin were significantly increased after radical operation, and long-term prognosis is poor.
本研究旨在探讨老年胃癌合并2型糖尿病（T2DM）患者根治性手术后血糖的变化。2007年1月至2017年1月期间，兰州大学第一医院对46例糖尿病组患者和30例非糖尿病组患者进行了根治性手术，并对临床资料进行了回顾性分析。进行统计分析以探讨根治性手术对两组患者血糖控制的影响。在46例胃癌合并T2DM患者中，24例接受了术后胰岛素干预，其余22例未接受胰岛素干预。后一组患者组成非胰岛素治疗组。比较两组患者的血糖控制情况、炎症标志物、肿瘤标志物及其对预后的影响。糖尿病组术后血糖水平显著高于非糖尿病组（P<0.05），而胰岛素治疗组血糖水平显著低于对照组（P<0.05）。胰岛素治疗组相关肿瘤标志物和炎症因子水平显著高于对照组（P<0.05）。胰岛素治疗组5年生存率显著高于对照组（P<0.05）。我们的结果表明，老年胃癌合并T2DM患者根治性手术后血糖水平显著升高，未使用胰岛素的老年胃癌合并T2DM患者根治性手术后血糖、肿瘤标志物和炎症因子水平显著升高，且长期预后较差。
