Incidental discovery of mucinous adenocarcinoma of the prostate following transurethral resection of the prostate: A report of two cases and a literature review.

Mucinous carcinoma is an unusual subtype of prostate cancer. In particular, mucinous adenocarcinomas identified following transurethral resection of the prostate (TURP) are extremely rare. The present study conducted are retrospective analysis of two cases of mucinous carcinoma of the prostate, which were incidentally diagnosed following histological examination of the specimens obtained by TURP. The pathological findings, treatment regimen and clinical course of the two cases were reviewed. One of the patients, whose surgical specimen stained positive for carcinoembryonic antigen (CEA) and negative for prostate-specific antigen (PSA), did not respond to androgen deprivation therapy (ADT). However, the other patient, whose specimen stained positive for PSA, was responsive to ADT, resulting in a better prognosis. Therefore, absence of PSA staining in surgical prostate specimens may be associated with a poor response to ADT and a worse prognosis.