一名复发型格雷夫斯病患者，对首次抗甲状腺药物（ATD）治疗耐受，但在第二次使用ATD时发生了抗甲状腺药物诱导的粒细胞缺乏症。
A case of antithyroid drug-induced agranulocytosis from a second antithyroid drugs (ATD) administration in a relapsed Graves' disease patient who was tolerant to the first ATD treatment.
作者信息
Kim Hyunsam, Lee Jeongmin, Ha Jeonghoon
机构信息
Division of Endocrinology and Metabolism Department of Internal Medicine College of Medicine Seoul St. Mary's Hospital The Catholic University of Korea Seoul Korea.
出版信息
Clin Case Rep. 2018 Jul 10;6(9):1701-1703. doi: 10.1002/ccr3.1644. eCollection 2018 Sep.
Abstract
Agranulocytosis is a rare side effect of antithyroid drugs (ATD) that usually develops within the first 3-6 months after starting treatment. We present a 64-year-old patient who developed agranulocytosis after starting ATD to treat relapsed Graves' disease. This patient had tolerated the first course of ATD for 72 months. This was an unusual case in which a serious side effect developed during a second ATD course. It is essential that clinicians remain vigilant to the fact that antithyroid drugs can induce agranulocytosis several years after initiated.
摘要
粒细胞缺乏症是抗甲状腺药物（ATD）罕见的副作用，通常在开始治疗后的最初3 - 6个月内出现。我们报告一名64岁患者，在开始使用ATD治疗复发的格雷夫斯病后发生了粒细胞缺乏症。该患者曾耐受第一疗程的ATD达72个月。这是一例不寻常的病例，在第二疗程的ATD治疗期间出现了严重的副作用。临床医生必须保持警惕，因为抗甲状腺药物在开始使用数年之后仍可诱发粒细胞缺乏症。
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