嘌呤和嘧啶增强甲氨蝶呤的治疗效果并保护正常增殖组织。
Enhancement of the therapeutic effectiveness of methotrexate and protection of normal proliferating tissues with purines and pyrimidines.
作者信息
Harrap K R, Taylor G A, Browman G P
出版信息
Chem Biol Interact. 1977 Jul;18(1):119-28. doi: 10.1016/0009-2797(77)90147-8.
PMID:302148
Abstract
Mice can be protected against the toxicity arising from lethal doses of methotrexate with purine and pyrimidine combinations, but not with pyrimidine alone. Furthermore, methotrexate treatment of tumour-bearing mice, conjunction with purine/pyrimidine protection, can be more effective than conventional metotrexate/folinic acid treatment.
摘要
嘌呤和嘧啶组合可保护小鼠免受致死剂量甲氨蝶呤产生的毒性影响，但单独使用嘧啶则无法起到保护作用。此外，对荷瘤小鼠进行甲氨蝶呤治疗并结合嘌呤/嘧啶保护，可能比传统的甲氨蝶呤/亚叶酸治疗更有效。
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