Törnquist Alba Lucia, Andersson Thomas, Winiarski Jacek, Grönlund Marita Andersson, Fahnehjelm Kristina Teär
Department of Clinical Neuroscience, Karolinska Institutet and St Erik Eye Hospital, Polhemsgatan 50, SE 112 82 Stockholm, Sweden.
Department of Clinical Neurophysiology, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Clin Neurophysiol Pract. 2017 Mar 2;2:67-71. doi: 10.1016/j.cnp.2017.02.001. eCollection 2017.
To study visual pathway pathology detected by visual evoked potentials (VEPs) in patients treated with hematopoietic stem cell transplantation (HSCT) in childhood and to determine the impact of adverse ocular findings, somatic diseases, and conditioning regimens on the VEP results.
Ophthalmological assessments including pattern VEPs were performed in 47 of 79 patients at a median age of 15 years (range 3-21 years) in median 6 years (1-17 years) after HSCT. Somatic data were extracted from medical records.
Eight patients of 47 (17%) demonstrated pathological VEPs with prolonged latencies bilaterally (n = 3) or unilaterally (n = 5) at their latest VEP test at an age of 12-18 years. A subnormal visual acuity was present in 8/11 eyes with pathological VEPs: one eye had cataract, six eyes had cataract surgery where of two had developed secondary cataracts. One eye had residual retinopathy of prematurity. Pathological VEPs were associated with decreased visual acuity (p = 0.00019) but not linked to gender, malignant diagnosis or conditioning.
VEP recordings showed an association with decreased visual acuity but no relationship with irradiation or chemotherapy in the present study.
VEP recordings might be of clinical value for children with an unexplained subnormal visual acuity undergoing HSCT.
研究儿童造血干细胞移植（HSCT）患者视觉诱发电位（VEP）检测到的视觉通路病理情况，并确定眼部不良发现、躯体疾病和预处理方案对VEP结果的影响。
对79例患者中的47例进行了眼科评估，包括图形VEP，这些患者的中位年龄为15岁（范围3 - 21岁），在HSCT后中位6年（1 - 17年）。从病历中提取躯体数据。
47例患者中有8例（17%）在12 - 18岁的最近一次VEP测试中表现出病理性VEP，双侧潜伏期延长（n = 3）或单侧潜伏期延长（n = 5）。11只患有病理性VEP的眼睛中有8只视力低于正常：1只眼睛有白内障，6只眼睛进行了白内障手术，其中2只出现了继发性白内障。1只眼睛有早产儿视网膜病变残留。病理性VEP与视力下降相关（p = 0.00019），但与性别、恶性诊断或预处理无关。
在本研究中，VEP记录显示与视力下降有关，但与放疗或化疗无关。
对于接受HSCT且视力 unexplained低于正常的儿童，VEP记录可能具有临床价值。 （注：“unexplained”原文如此，可能有误，推测应为“unexplainedly”之类的词，但按要求未改动）
