Italian National Institute for Health, Environment and Health Department, Viale Regina Elena, 299, 00161, Rome, Italy.
Department of Biomedical Sciences - Histology, University of Sassari, Sassari, Italy.
Biol Trace Elem Res. 2019 Jul;190(1):1-10. doi: 10.1007/s12011-018-1509-5. Epub 2018 Sep 13.
Systemic sclerosis (SSc) is a multisystem connective tissue disease; exogenous factors-including heavy metals-may have a role in the disease pathogenesis. In this context, a study on the quantification of Al, Cd, Hg, and Pb in blood and urine of 27 SSc patients and 30 controls was carried out. Main findings were that Al was significantly depleted in blood and increased in urine of SSc patients respect to controls; and Pb was found slightly increased in blood and significantly decreased in SSc group. In addition, higher Hg levels in urine were found in SSc subjects with the higher severity of the disease. Females showed the most marked differences in the levels of blood Al, blood Pb, and urine Cd between patients and controls. Smoking, hobby, ingestion of contaminated food, job exposure may contribute to the bodily levels of Al, Hg, Pb in SSc patients. The results indicated that low, chronic, and multiple exposures to heavy metals-also through habits, diet, and environment-may influence the risk for SSc.
系统性硬化症（SSc）是一种多系统结缔组织疾病；外源性因素，包括重金属，可能在疾病发病机制中起作用。在此背景下，对 27 名 SSc 患者和 30 名对照者的血液和尿液中的 Al、Cd、Hg 和 Pb 进行了定量研究。主要发现是 SSc 患者的血液中 Al 明显减少，而尿液中 Al 增加；并且在 SSc 组中发现 Pb 略有增加，而血液中 Pb 明显减少。此外，在疾病严重程度较高的 SSc 患者的尿液中发现了更高水平的 Hg。女性在患者和对照组之间的血液 Al、血液 Pb 和尿液 Cd 水平上表现出最明显的差异。吸烟、爱好、摄入受污染的食物、职业暴露可能导致 SSc 患者体内 Al、Hg、Pb 水平升高。研究结果表明，低水平、慢性和多重暴露于重金属——也通过习惯、饮食和环境——可能会影响 SSc 的风险。
