Section of Neurology, Kaohsiung Veterans General Hospital, No. 386, Ta-Chung 1st Rd., Kaohsiung, Taiwan.
Department of Electrical Engineering, Southern Taiwan University of Science and Technology, No. 1, Nan-Tai Street, Yongkang Dist., Tainan, Taiwan.
Medicine (Baltimore). 2022 Mar 4;101(9):e28973. doi: 10.1097/MD.0000000000028973.
Cerebrovascular disease is the second commonest cause of mortality globally and among the commonest causes of disability. However, research executed to probe the heavy metal exposure-stroke incidence relationship is scarce. Accordingly, we executed our study to probe the relationship of heavy metal concentrations (ie, concentrations of lead [Pb], mercury [Hg], cadmium [Cd], and arsenic) in the serum and urine of acute ischemic stroke (AIS) patients with several patient variables.For enrollment, we chose patients who had a first AIS within 7 days after the onset of a stroke. Thus, 33 newly diagnosed patients with AIS were recruited. We determined the aforementioned metals' concentrations by executing inductively coupled plasma mass spectrometry. We also gauged the association between such metal concentrations and patient variables by employing Spearman correlation coefficient. To examine the differences in metal concentrations between the different variables, we implemented an independent Mann-Whitney U test.In our cohort analysis, we noted serum Pb and Cd concentrations to be positively correlated with serum creatinine and hemoglobin. Serum and urine Cd concentrations had a negative correlation with impaired HbA1c in AIS patients. Urine Hg had a positive correlation with C-reactive protein in the participants. Participants who smoked or consumed alcohol had significantly higher Pb and Cd levels in serum than did those who neither smoked nor drank. Patients with AIS who smoked or consumed alcohol had high levels of serum Pb and serum Cd than did those who did not. Patients with AIS who consumed alcohol had significantly higher Pb and Hg urine concentrations than did those who did not.Our study indicated that serum Cd and Pb elevation increased the AIS risk in southern Taiwan patients.
脑血管疾病是全球第二大致死原因，也是最常见的致残原因之一。然而，针对重金属暴露与中风发病率之间关系的研究却很少。因此，我们进行了这项研究，以探讨急性缺血性中风（AIS）患者血清和尿液中重金属浓度（即铅[Pb]、汞[Hg]、镉[Cd]和砷）与多种患者变量之间的关系。
在入组时，我们选择了在中风发作后 7 天内首次发生 AIS 的患者。因此，我们招募了 33 名新诊断的 AIS 患者。我们通过执行电感耦合等离子体质谱法来确定上述金属的浓度。我们还通过 Spearman 相关系数来衡量这些金属浓度与患者变量之间的关联。为了检查不同变量之间金属浓度的差异，我们采用了独立的 Mann-Whitney U 检验。
在我们的队列分析中，我们注意到血清 Pb 和 Cd 浓度与血清肌酐和血红蛋白呈正相关。血清和尿液 Cd 浓度与 AIS 患者 HbA1c 受损呈负相关。尿液 Hg 与参与者的 C-反应蛋白呈正相关。吸烟或饮酒的参与者的血清 Pb 和 Cd 水平明显高于既不吸烟也不饮酒的参与者。吸烟或饮酒的 AIS 患者的血清 Pb 和血清 Cd 水平明显高于不吸烟或不饮酒的患者。饮酒的 AIS 患者的血清 Pb 和 Hg 尿浓度明显高于不饮酒的患者。
我们的研究表明，血清 Cd 和 Pb 升高增加了台湾南部患者的 AIS 风险。
