硒标记化合物的合成——II. 与元素硒的交换反应。
Syntheses of selenium labelled compounds--II. The exchange reaction with elemental selenium.
作者信息
Ogawa K, Taki K
出版信息
Int J Rad Appl Instrum A. 1986;37(4):315-8. doi: 10.1016/0883-2889(86)90120-6.
73Se labelled 2-selenouracil was prepared by the isotope exchange reaction method. It has been well known that in order to prepare labelled compounds in high specific activity by exchange reaction, the substrate compounds have to be used in small quantities. For 2-selenouracil, however, the reaction in low concentration is not always preferable for the labelling of high specific activity within a limited time. The optimum conditions for the preparation of [2-73Se]-2-selenouracil of maximum specific activity were determined.
通过同位素交换反应法制备了73Se标记的2-硒尿嘧啶。众所周知，为了通过交换反应制备高比活度的标记化合物，底物化合物必须少量使用。然而，对于2-硒尿嘧啶来说，在有限时间内进行低浓度反应并不总是有利于制备高比活度的标记物。确定了制备最大比活度的[2-73Se]-2-硒尿嘧啶的最佳条件。
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