Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
Diabetes and Bone-Metabolic Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark.
Pediatr Blood Cancer. 2019 Jan;66(1):e27437. doi: 10.1002/pbc.27437. Epub 2018 Sep 14.
Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow-up of 4.2 years (range: 1.7-9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin-dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.
胰腺炎是急性淋巴细胞白血病（ALL）治疗中的常见毒性反应，与门冬酰胺酶的使用显著相关，并且可能会导致严重的并发症，如急性高血糖、需要机械通气、假性囊肿和死亡。在这里，我们提供了七名在胰腺炎诊断后患有糖尿病且在中位随访 4.2 年后仍需胰岛素治疗的患者的新数据（范围：1.7-9.2 年）。我们描述了胰腺炎的临床过程，并说明了胰腺假性囊肿、年龄较大和发生胰岛素依赖型糖尿病之间的关联。总之，这项研究记录了儿童 ALL 中胰腺炎的持续负担，并强调了监测血糖水平的必要性。
