Department of Pediatric Allergy and Immunology, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Division of Pediatric Allergy and Immunology, Department of Children's Health and Diseases, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
Ann Allergy Asthma Immunol. 2019 Jan;122(1):73-78.e1. doi: 10.1016/j.anai.2018.09.447. Epub 2018 Sep 12.
Children may be referred to pediatric allergy clinics for reactions to multiple drugs. Multiple drug hypersensitivity (MDH) is defined as immunologically-mediated hypersensitivity to 2 or more chemically different drugs.
The aim of this study is to report the allergy workup results of children who had a history of potential hypersensitivity reactions to 2 or more unrelated drugs.
This study was conducted in the Pediatric Allergy and Immunology department of our hospital. Children who described hypersensitivity reactions to 2 or more drugs were included and were evaluated by allergy workup (skin and/or provocation tests) between January 2011 and July 2016.
During the study period, 886 children were evaluated for a history of drug intolerance. Of these children, 73 (8.2%) had a history of drug reactions to 2 or more chemically different drugs. The median age of the children who had a history of reactions to 2 or more drugs was 7.8 (min-max: 2.5-16.4) years, and 59% (n = 43) were male. Among the suspected drugs, antibiotics (65.9%) ranked first, and nonsteroid anti-inflammatory drugs (34.1%) were the second. All 73 children were evaluated with skin or provocation tests with the suspected drugs, and MDH was confirmed in only 2 (2.7%) children.
Multiple drug hypersensitivity is uncommon in children. The incidence and prevalence of MDH may vary with the specific population studied. Evaluating children with a history of MDH, by performing drug hypersensitivity testing, will help avoid the morbidity associated with unnecessary drug avoidance.
儿童可能因对多种药物的反应而被转介至儿科过敏诊所。多种药物过敏反应（MDH）定义为对 2 种或以上化学结构不同的药物发生免疫介导的过敏反应。
本研究旨在报告曾有 2 种或以上非相关药物潜在过敏反应史的儿童的过敏评估结果。
本研究在我院儿科过敏和免疫科进行。纳入曾描述对 2 种或以上药物发生过敏反应的儿童，并于 2011 年 1 月至 2016 年 7 月期间通过过敏评估（皮肤和/或激发试验）进行评估。
在研究期间，有 886 名儿童因药物不耐受而接受评估。其中 73 名（8.2%）儿童有 2 种或以上化学结构不同药物的过敏反应史。有 2 种或以上药物过敏反应史的儿童的中位年龄为 7.8 岁（最小-最大：2.5-16.4 岁），59%（n=43）为男性。在可疑药物中，抗生素（65.9%）排名第一，非甾体抗炎药（34.1%）排名第二。所有 73 名儿童均接受了可疑药物的皮肤或激发试验评估，仅 2 名（2.7%）儿童被确诊为 MDH。
儿童的 MDH 并不常见。MDH 的发病率和患病率可能因所研究的特定人群而异。通过进行药物过敏测试来评估有 MDH 病史的儿童，有助于避免因不必要的药物回避而导致的发病率。
