The children's hospital affiliated of Suzhou University, Suzhou 215000, Jiangsu Province, China.
Children Asthma Department, Lianyungang Maternal and Child Hospital Jiangsu Province, Lianyungang 222006, Jiangsu Province, China.
Clin Chim Acta. 2018 Dec;487:75-79. doi: 10.1016/j.cca.2018.09.023. Epub 2018 Sep 12.
Runx3, a member of the Runt-related transcription factor family, has attracted extensive attention due to its important role in the development of immune systems, especially in the differentiation of T cells. Accumulated evidence indicated that altered expression of Runx3 regulates a variety of target genes in different tissues/cells. Studies in animal models suggested that Runx3 may regulate the development of T cell lineage including those of innate lymphoid cells, Treg cells and dendritic cells, which may contribute to the development of hypersensitivity and asthma. Specifically, Runx3 modulates Th1/Th2 balance and hence, the production of interleukins, which induce inflammatory responses. Understanding the roles and mechanisms of Runx3 in the regulation of immune function provides a basis for the design of novel preventive and treatment models for bronchial asthma. This article reviews published data from cell lines, animal models, and patients, concerning the relationship between Runx3 expression alteration and asthma. Epigenetic regulation of Runx3 by DNA hypermethylation and microRNA, and the implication of these pathways in asthma are also discussed.
Runx3 是 Runt 相关转录因子家族的成员，由于其在免疫系统发育中的重要作用，特别是在 T 细胞分化中，引起了广泛关注。有大量证据表明，Runx3 的表达改变可调节不同组织/细胞中的多种靶基因。动物模型研究表明，Runx3 可能调节 T 细胞谱系的发育，包括先天淋巴细胞、Treg 细胞和树突状细胞，这可能有助于过敏和哮喘的发展。具体而言，Runx3 调节 Th1/Th2 平衡，从而调节白细胞介素的产生，诱导炎症反应。了解 Runx3 在免疫功能调节中的作用和机制，为设计支气管哮喘的新型预防和治疗模型提供了依据。本文综述了关于 Runx3 表达改变与哮喘之间关系的细胞系、动物模型和患者的已发表数据。还讨论了 DNA 高甲基化和 microRNA 对 Runx3 的表观遗传调控及其在哮喘中的意义。
