I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya 8-2, Moscow 119991, Russian Federation.
I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya 8-2, Moscow 119991, Russian Federation.
J Neurol Sci. 2018 Nov 15;394:75-77. doi: 10.1016/j.jns.2018.08.023. Epub 2018 Aug 23.
Mild cognitive impairment (MCI) in patients with cardiovascular risks is a transitional state to vascular dementia but which still has a possibility of being managed. The objectives of this study were to assess the impact of atrial fibrillation (AF) on cognitive performances in the elderly in comparison with similar cardiovascular risks. One hundred unselected patients were included in AF+ and AF- groups. Patients with prodromal Alzheimer disease as shown by semantic cueing test, and those suffering from major cognitive decline according to DSM 5 criteria were evaluated separately from those patients analysed for vascular cognitive impairment. MCI was distinguished with the help of the Montreal cognitive assessment and the mood status was studied with the geriatric depression scale. AF+ patients predominantly had paroxysmal type of AF with a mean duration of 6.3 years, with 77% of the patients being on anticoagulation. AF- patients had arterial hypertension. Prevalence of MCI was significantly higher among AF- patients, possibly due to lower rates of BP control. These study results show less impact of AF itself on cognitive performances in comparison with uncontrolled hypertension.
心血管风险患者的轻度认知障碍（MCI）是血管性痴呆的过渡状态，但仍有可能得到控制。本研究的目的是评估与相似心血管风险相比，房颤（AF）对老年人认知表现的影响。100 名未经选择的患者被纳入 AF+ 和 AF- 组。通过语义提示测试显示有前驱性阿尔茨海默病的患者，以及根据 DSM 5 标准患有严重认知衰退的患者，与那些分析血管性认知障碍的患者分开评估。使用蒙特利尔认知评估来区分 MCI，使用老年抑郁量表来研究情绪状态。AF+ 患者主要为阵发性 AF，平均持续时间为 6.3 年，77%的患者接受抗凝治疗。AF- 患者患有高血压。与 AF- 患者相比，MCI 在 AF- 患者中的发生率明显更高，这可能是由于血压控制率较低。这些研究结果表明，与未控制的高血压相比，AF 本身对认知表现的影响较小。
