Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA; Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, USA.
Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Trends Neurosci. 2018 Nov;41(11):765-767. doi: 10.1016/j.tins.2018.08.012. Epub 2018 Sep 12.
In 1996, Hyejin Kang and Erin Schuman, in search of new functions for the secreted growth factor brain-derived neurotrophic factor (BDNF), identified the protein synthesis requirement of BDNF in regulating synaptic plasticity. This landmark paper identified one of the first tractable pathways in the quest to dissect the complex process of synaptic remodeling and revealed the critical role for this neurotrophin in regulating long-term memory.
1996 年，Hyejin Kang 和 Erin Schuman 在寻找分泌型生长因子脑源性神经营养因子（BDNF）的新功能时，发现 BDNF 调节突触可塑性需要蛋白质合成。这篇具有里程碑意义的论文确定了在剖析突触重塑这一复杂过程中第一个可处理的途径之一，并揭示了这种神经营养因子在调节长期记忆中的关键作用。
