Chu J S, Liu T H, Zang Y Z, Wang K L, Ma H Z, Han C L, Zhao X B, Liu Y P, Xia X T, Meng F G
Department of Neurosurgery, Beijing Tiantan Hospital, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.
Zhonghua Yi Xue Za Zhi. 2018 Sep 4;98(33):2632-2635. doi: 10.3760/cma.j.issn.0376-2491.2018.33.004.
To investigate the characteristics of cerebral metabolism associated with mild cognitive impairment (MCI) Parkinson's disease (PD), cognitive normal PD and normal control to find a PET biomarker for the diagnose and estimate of PD-MCI. Forty-seven patients diagnosed with PD (included 15 with mild cognitive impairment) and 20 control subjects were enrolled. All the subjects were evaluated with FDG-PET and clinical scale. The statistical parametric mapping (SPM) were analyzed to determine metabolic patterns that may be useful in differentiating between the three groups. SPM analysis showed that significant hypometabolism were observed in both side of front lobe, parietal lobe, left temporal lobe and left occipital lobe; in the contrast, the relative hypermetabolism had been observed in the cerebellum, vermis, hippocampus and supplement motor area (SMA) in patients with PD-MCI. PD without MCI showed hypometabolism in both side of front lob, caudate and putamen. PD-MCI showed that the significant hypermetabolism were in the insular and cerebellum while hypometabolism were in the both side of occipital compared to PD without MCI. A voxel-by-voxel based SPM method i. e. SPM8 analysis by PET scan is an effective way to analysis the FDG uptake pattern of PD patients. The hypermetabolism in the insula and cerebellum and hypometabolism in the both side of occipital may be a biomarker for make a diagnosis of PD-MCI.
为研究轻度认知障碍（MCI）帕金森病（PD）、认知功能正常的PD及正常对照者的脑代谢特征，以寻找用于诊断和评估PD-MCI的PET生物标志物。纳入47例诊断为PD的患者（包括15例轻度认知障碍患者）及20例对照者。所有受试者均接受FDG-PET及临床量表评估。采用统计参数映射（SPM）分析以确定可能有助于区分三组的代谢模式。SPM分析显示，额叶、顶叶双侧、左侧颞叶及左侧枕叶均存在明显代谢减低；相比之下，PD-MCI患者的小脑、蚓部、海马及辅助运动区（SMA）存在相对代谢增高。无MCI的PD患者额叶双侧、尾状核及壳核存在代谢减低。与无MCI的PD相比，PD-MCI患者岛叶和小脑存在明显代谢增高，而枕叶双侧存在代谢减低。基于体素的SPM方法，即通过PET扫描进行SPM8分析，是分析PD患者FDG摄取模式的有效方法。岛叶和小脑代谢增高以及枕叶双侧代谢减低可能是诊断PD-MCI的生物标志物。
