Suga J, Saijo N, Shinkai T, Eguchi K, Sasaki Y, Tamura T, Sakurai M, Sano T, Ono R, Takahashi H
Jpn J Clin Oncol. 1986 Sep;16(3):309-15.
Of the 66 patients with small cell lung cancer (SCLC) who were treated by combination chemotherapy with or without radiation therapy from July 1978 to December 1983 at the National Cancer Center Hospital, Tokyo, 12 (18%) survived over two years and nine (14%) have remained disease-free over three years. The two-year survival rates were compared according to the patient characteristics of sex, performance status (PS), extent of disease, histologic subtype, regimen of the initial chemotherapy and response to treatment. Sex, extent of disease and response to the initial chemotherapy were the most important prognostic factors. The prognosis for patients with liver or bone metastasis was poor. All disease-free survivors, except for two patients who were treated by surgical resection after chemotherapy, achieved complete response (CR) with chemotherapy with or without radiation therapy. Eleven of the 12 two-year survivors achieved CR. Because of the small number of patients in our study, it will be necessary to evaluate further the influence of prognostic factors in patients with SCLC in future studies.
1978年7月至1983年12月期间，东京国立癌症中心医院对66例小细胞肺癌（SCLC）患者进行了联合化疗，部分患者还接受了放射治疗。其中12例（18%）存活超过两年，9例（14%）无疾病生存超过三年。根据患者的性别、体能状态（PS）、疾病范围、组织学亚型、初始化疗方案及治疗反应等特征对两年生存率进行了比较。性别、疾病范围及对初始化疗的反应是最重要的预后因素。肝转移或骨转移患者的预后较差。除了两名化疗后接受手术切除的患者外，所有无疾病生存者均通过化疗联合或不联合放射治疗实现了完全缓解（CR）。12例两年生存者中有11例实现了CR。由于本研究中的患者数量较少，未来有必要在进一步的研究中评估预后因素对SCLC患者的影响。
