Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
BJOG. 2019 Feb;126(3):402-411. doi: 10.1111/1471-0528.15471. Epub 2018 Oct 23.
To assess the short- and long-term effects of mindfulness-based stress reduction (MBSR) on the resulting quality of life, sexual functioning, and sexual distress after risk-reducing salpingo-oophorectomy (RRSO).
Randomised controlled trial.
A specialised family cancer clinic of the university medical center Groningen.
Sixty-six women carriers of the BRCA1/2 mutation who developed at least two moderate-to-severe menopausal symptoms after RRSO.
Women were randomised to an 8-week MBSR training programme or to care as usual (CAU).
Change in the Menopause-Specific Quality of Life Questionnaire (MENQOL), the Female Sexual Function Index, and the Female Sexual Distress Scale, administered from baseline at 3, 6, and 12 months. Linear mixed modelling was applied to compare the effect of MBSR with CAU over time.
At 3 and 12 months, there were statistically significant improvements in the MENQOL for the MBSR group compared with the CAU group (both P = 0.04). At 3 months, the mean MENQOL scores were 3.5 (95% confidence interval, 95% CI 3.0-3.9) and 3.8 (95% CI 3.3-4.2) for the MBSR and CAU groups, respectively; at 12 months, the corresponding values were 3.6 (95% CI 3.1-4.0) and 3.9 (95% CI 3.5-4.4). No significant differences were found between the MBSR and CAU groups in the other scores.
Mindfulness-based stress reduction was effective at improving quality of life in the short- and long-term for patients with menopausal symptoms after RRSO; however, it was not associated with an improvement in sexual functioning or distress.
Mindfulness improves menopause-related quality of life in women after risk-reducing salpingo-oophorectomy.
评估正念减压（MBSR）对降低风险的输卵管卵巢切除术（RRSO）后生活质量、性功能和性困扰的短期和长期影响。
随机对照试验。
格罗宁根大学医学中心的一个专门的家庭癌症诊所。
66 名携带 BRCA1/2 突变的女性，RRSO 后至少出现 2 种中度至重度绝经症状。
将女性随机分配到 8 周的 MBSR 训练计划或常规护理（CAU）。
使用绝经特异性生活质量问卷（MENQOL）、女性性功能指数和女性性困扰量表，在基线、3 个月、6 个月和 12 个月进行测量，以评估 MBSR 与 CAU 随时间的变化。线性混合模型用于比较 MBSR 与 CAU 的效果。
在 3 个月和 12 个月时，与 CAU 组相比，MBSR 组的 MENQOL 评分有统计学意义的改善（均 P = 0.04）。在 3 个月时，MBSR 和 CAU 组的 MENQOL 评分分别为 3.5（95%置信区间，95%CI 3.0-3.9）和 3.8（95%CI 3.3-4.2）；在 12 个月时，相应的评分分别为 3.6（95%CI 3.1-4.0）和 3.9（95%CI 3.5-4.4）。在其他评分方面，MBSR 组和 CAU 组之间没有发现显著差异。
MBSR 可在 RRSO 后有绝经症状的患者中在短期和长期内有效改善生活质量，但与性功能或困扰的改善无关。
MBSR 可改善 RRSO 后女性与绝经期相关的生活质量。
