Pibrentasvir has not been studied in nursing mothers being treated for hepatitis C infection. Because it is >99.9% bound to maternal plasma proteins, amounts in breastmilk are likely to be very low. Hepatitis C is not transmitted through breastmilk and breastmilk has been shown to inactivate hepatitis C virus (HCV).[1–4] However, the Centers for Disease Control recommends that mothers with HCV infection should consider abstaining from breastfeeding if their nipples are cracked or bleeding. It is not clear if this warning would apply to mothers who are being treated for hepatitis C. Infants born to mothers with HCV infection should be tested for HCV infection; because maternal antibody is present for the first 18 months of life and before the infant mounts an immunologic response, nucleic acid testing is recommended.[1,4]
尚未在接受丙型肝炎感染治疗的哺乳期母亲中对匹布伦特斯韦进行研究。由于其与母体血浆蛋白的结合率>99.9%，母乳中的含量可能非常低。丙型肝炎不会通过母乳传播，并且已证明母乳可使丙型肝炎病毒（HCV）失活。[1-4] 然而，疾病控制中心建议，丙型肝炎感染母亲的乳头如有皲裂或出血，应考虑停止母乳喂养。尚不清楚这一警告是否适用于正在接受丙型肝炎治疗的母亲。丙型肝炎感染母亲所生婴儿应接受丙型肝炎感染检测；由于母体抗体在婴儿出生后的前18个月存在，且在婴儿产生免疫反应之前，建议进行核酸检测。[1,4]
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