Honma K, Honma S, Hirai T, Katsuno Y, Hiroshige T
Physiol Behav. 1986;37(5):791-5. doi: 10.1016/0031-9384(86)90186-1.
The roles of food and/or water ingestion in the regulation of plasma corticosterone level were examined in rats under restricted daily feeding. When the time of food-pellets and water supply was restricted to 2 hours in the early light period (meal feeding) for 2 weeks, the corticosterone level increased prior to meal (prefeeding peak). A similar prefeeding hormone peak was observed when supply of food-pellets was restricted to 2 hours with free-access to water (food restriction). In contrast, when water supply was restricted to 2 hours with free-access to food-pellets (water restriction), the hormone level before water supply did not increase as much as that under meal feeding or food restriction. Shortening of an available time for water under water restriction or prolongation of the restriction schedule failed to elevate the hormone level furthermore. On the other hand, the high prefeeding corticosterone level before meal decreased subsequently to meal feeding (prandial fall), which was not observed when rats were kept fasting during the meal time. This prandial fall of the hormone level was not observed by water intake alone, and closely related to food-pellets ingestion. It is concluded that food ingestion is more important than water intake to the formation of the prefeeding corticosterone peak and to the prandial fall of the hormone level under restricted daily feeding.
在每日限时喂食的大鼠中，研究了食物和/或水摄入在调节血浆皮质酮水平中的作用。当在早光照期将颗粒饲料和水的供应时间限制为2小时（进餐式喂食），持续2周时，皮质酮水平在进餐前升高（喂食前峰值）。当颗粒饲料供应限制为2小时且可自由饮水时（食物限制），也观察到类似的喂食前激素峰值。相反，当水供应限制为2小时且可自由获取颗粒饲料时（水限制），供水前的激素水平升高幅度不如进餐式喂食或食物限制时大。在水限制情况下缩短水的可获取时间或延长限制时间，均未能进一步提高激素水平。另一方面，进餐前较高的喂食前皮质酮水平在进餐后随后下降（餐后下降），而当大鼠在进餐时间禁食时未观察到这种情况。仅饮水未观察到激素水平的这种餐后下降，且其与颗粒饲料摄入密切相关。得出的结论是，在每日限时喂食情况下，食物摄入对于喂食前皮质酮峰值的形成以及激素水平的餐后下降比水摄入更为重要。
