Venugopalan C S, Jenkins H J, Drazen J M
Res Commun Chem Pathol Pharmacol. 1986 Sep;53(3):275-88.
Cumulative concentration-effect relationships of isoproterenol (isoprenaline) on guinea pig tracheal spirals and lung parenchymal strips were determined in organ baths kept at 37 degrees C or at 18 degrees C. The IC50's for isoproterenol at 18 degrees C were significantly (p less than .01) higher than those for isoproterenol at 37 degrees C in both the tissues; although the parenchymal response was affected more than that of the trachea by cooling. pA2 values for propranolol were determined on both tracheal spirals and parenchymal strips at 37 degrees C and 18 degrees C. The pA2 values were decreased in both the tissues by cooling. The decrease was more prominent in the parenchyma than in the trachea, a finding consistent with the concentration-effect relationships studies mentioned above.
在37摄氏度或18摄氏度的器官浴中测定了异丙肾上腺素对豚鼠气管螺旋条和肺实质条的累积浓度-效应关系。在两种组织中，18摄氏度时异丙肾上腺素的IC50均显著高于37摄氏度时的IC50（p<0.01）；尽管冷却对实质条反应的影响大于对气管的影响。在37摄氏度和18摄氏度下，分别在气管螺旋条和肺实质条上测定了普萘洛尔的pA2值。冷却使两种组织的pA2值均降低。这种降低在肺实质中比在气管中更显著，这一发现与上述浓度-效应关系研究一致。
