Mucke W, Brüschke G
Z Gesamte Inn Med. 1986 Aug 15;41(16):441-6.
The influence of the pancreatic secretion on the absorption of iron supposed by several authors could be ascertained by the investigation of pancreatic juice which was obtained by means of cannulation of the pancreatic duct and subsequent stimulation of the organ with secretin pancreozymin in patients with haemochromatosis. The absorption of iron increased in this disease can on the one hand be caused by a protracted secretion of hydrogen carbonate and the slower decrease of the pH-value in the upper duodenum, on the other hand by an increased secretion of pancreatic protein. The quantity of hydrogen carbonate decides on the speed of neutralisation of the formerly acid chyme, however, together with the proteins being at the disposal on the formation of absorption-promoting iron-chelates or of not bioavailable, partly polymeric iron hydroxides.
几位作者推测的胰腺分泌对铁吸收的影响，可以通过对患有血色素沉着症的患者进行胰管插管并随后用促胰液素-促胰酶素刺激该器官来获取胰液进行研究加以确定。在这种疾病中，铁吸收增加一方面可能是由于碳酸氢盐的持续分泌以及十二指肠上段pH值下降较慢，另一方面可能是由于胰腺蛋白分泌增加。碳酸氢盐的量决定了先前酸性食糜的中和速度，然而，它与可用于形成促进吸收的铁螯合物或不可生物利用的部分聚合氢氧化铁的蛋白质共同起作用。
