Bakarev M A, Levin V P, Kachesov I V, Abdullaev N A, Neimark A I
Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
Altai State Medical University, Ministry of Health of Russia, Barnaul, Russia.
Bull Exp Biol Med. 2018 Sep;165(5):682-687. doi: 10.1007/s10517-018-4241-4. Epub 2018 Sep 17.
Immunohistochemical and morphometric analysis of the microcirculatory bed in the tumor and non-tumor parenchyma of the prostate was carried out with the use of endothelial cell marker CD34 in patients treated by high-intensity focused ultrasound (HIFU). The numerical density of microvessels in the adenocarcinoma focus did not correlate with the degree of its differentiation, while high values of this parameter were associated with lower incidence of local progression after HIFU. Effective HIFU ablation led to progressive fibrosis and significant reduction of the microcirculatory bed in zones of intact non-tumor glands in control samples; an inverse relationship between the degree of reduction of the microcirculatory bed and the probability of relapse was revealed. The use of HIFU in combination with androgen deprivation was associated with a decrease in numerical density of microvessels in zones of tumor and non-tumor parenchyma in patients with relapses.
对接受高强度聚焦超声（HIFU）治疗的患者，使用内皮细胞标志物CD34对前列腺肿瘤及非肿瘤实质的微循环床进行了免疫组织化学和形态计量分析。腺癌灶内微血管的数值密度与其分化程度无关，而该参数的高值与HIFU治疗后局部进展的低发生率相关。有效的HIFU消融导致对照样本中完整非肿瘤腺体区域出现进行性纤维化和微循环床显著减少；揭示了微循环床减少程度与复发概率之间的负相关关系。HIFU与雄激素剥夺联合使用与复发患者肿瘤及非肿瘤实质区域微血管数值密度降低有关。
