Melby J C
Am J Med. 1986 Oct 31;81(4C):8-12. doi: 10.1016/0002-9343(86)90938-1.
Both the thiazide and loop diuretics have long been known to induce both potassium and magnesium wastage with resultant negative balances of these important intracellular cations. The negative potassium and magnesium balances resulting from diuretic therapy are due primarily to stimulation of the renin-angiotensin-aldosterone complex or secondary hyperaldosteronism. A long experience with an attempt to modify or reduce diuretic-induced potassium depletion by dietary sodium restriction and by the use of antikaluretics has been recorded.
长期以来，人们都知道噻嗪类利尿剂和袢利尿剂都会导致钾和镁的流失，从而使这些重要的细胞内阳离子出现负平衡。利尿治疗导致的钾和镁负平衡主要是由于肾素 - 血管紧张素 - 醛固酮复合物受到刺激或继发性醛固酮增多症。关于通过限制饮食中的钠以及使用抗利钾剂来改变或减少利尿剂引起的钾缺乏的长期经验已有记载。
