Hamamoto Hiroshi
Jpn J Antibiot. 2016 Oct;69(5):301-308.
We established silkworm infection model for developing a novel antibiotic. Silkworm model has less ethical issues and is low cost compared to mammalian model, thus allow us to use a lot of individuals for screening assay. In addition, we can evaluate therapeutic activity and toxicity of candidate samples because silkworm has similar pharmacokinetics as mammals. Using this system, we identified a novel antibiotic named "Lysocin E". In this review article, we describe advantages of silkworm model for development of antimicrobial agents.
我们建立了用于开发新型抗生素的家蚕感染模型。与哺乳动物模型相比，家蚕模型存在的伦理问题较少且成本较低，因此我们可以使用大量个体进行筛选试验。此外，由于家蚕具有与哺乳动物相似的药代动力学，我们可以评估候选样品的治疗活性和毒性。利用该系统，我们鉴定出一种名为“溶菌素E”的新型抗生素。在这篇综述文章中，我们描述了家蚕模型在抗菌剂开发方面的优势。
