Suppr超能文献

阐明GABA能皮质中间神经元亚型的发育轨迹。

Elucidating the developmental trajectories of GABAergic cortical interneuron subtypes.

作者信息

Miyoshi Goichi

机构信息

Department of Neurophysiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan.

出版信息

Neurosci Res. 2019 Jan;138:26-32. doi: 10.1016/j.neures.2018.09.012. Epub 2018 Sep 15.

Abstract

GABAergic interneurons in the neocortex play pivotal roles in the feedforward and feedback inhibition that control higher order information processing and thus, malfunction in the inhibitory circuits often leads to neurodevelopmental disorders. Very interestingly, a large diversity of morphology, synaptic targeting specificity, electrophysiological properties and molecular expression profiles are found in cortical interneurons, which originate within the distantly located embryonic ganglionic eminences. Here, I will review the still ongoing effort to understand the developmental trajectories of GABAergic cortical interneuron subtypes.

摘要

新皮层中的γ-氨基丁酸能中间神经元在前馈和反馈抑制中发挥关键作用,这些抑制控制着高阶信息处理,因此,抑制性回路的功能失调常常导致神经发育障碍。非常有趣的是,在皮质中间神经元中发现了形态、突触靶向特异性、电生理特性和分子表达谱的巨大多样性,这些神经元起源于位于远处的胚胎神经节隆起。在这里,我将综述目前仍在进行的关于了解γ-氨基丁酸能皮质中间神经元亚型发育轨迹的研究工作。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验