Miyoshi Goichi
Department of Neurophysiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan.
Neurosci Res. 2019 Jan;138:26-32. doi: 10.1016/j.neures.2018.09.012. Epub 2018 Sep 15.
GABAergic interneurons in the neocortex play pivotal roles in the feedforward and feedback inhibition that control higher order information processing and thus, malfunction in the inhibitory circuits often leads to neurodevelopmental disorders. Very interestingly, a large diversity of morphology, synaptic targeting specificity, electrophysiological properties and molecular expression profiles are found in cortical interneurons, which originate within the distantly located embryonic ganglionic eminences. Here, I will review the still ongoing effort to understand the developmental trajectories of GABAergic cortical interneuron subtypes.
新皮层中的γ-氨基丁酸能中间神经元在前馈和反馈抑制中发挥关键作用，这些抑制控制着高阶信息处理，因此，抑制性回路的功能失调常常导致神经发育障碍。非常有趣的是，在皮质中间神经元中发现了形态、突触靶向特异性、电生理特性和分子表达谱的巨大多样性，这些神经元起源于位于远处的胚胎神经节隆起。在这里，我将综述目前仍在进行的关于了解γ-氨基丁酸能皮质中间神经元亚型发育轨迹的研究工作。
