Departments of Pediatrics, Pediatric Neurosciences, Neuroscience and Mental Health Institute, Integrative Health Institute, Faculty of Medicine & Dentistry, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, Alberta, Canada.
Departments of Pediatrics, Pediatric Neurosciences, Neuroscience and Mental Health Institute, Integrative Health Institute, Faculty of Medicine & Dentistry, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, Alberta, Canada.
Pharmacol Res. 2019 Jan;139:228-242. doi: 10.1016/j.phrs.2018.08.022. Epub 2018 Sep 15.
The majority of brain injuries that lead to cerebral palsy, developmental disability, and mental health disorders have their onset in utero. These lifelong conditions come with great economic and emotional burden as they impact function in nearly all domains of affected individuals' lives. Unfortunately, current therapeutic options are limited. There remains a focus on rescue, rehabilitation, and regeneration after the injury has occurred, rather than aiming to prevent the initial injury. Prevention would imply treating the mother during pregnancy to alter the fetal environment and in turn, treat the fetus. Fear of harming the developing fetus remains as a result of errors of the past such as the release of thalidomide. In this review, we outline evidence from animal studies and clinical trials that have explored maternal dietary supplementation with natural health products (including nutraceuticals and functional foods) for perinatal brain injury prevention. Namely, we discuss magnesium sulphate, creatine, choline, melatonin, resveratrol and broccoli sprouts/sulforaphane. Although clinical trials have only been completed in this realm for magnesium sulphate, results in animal models have been promising, suggesting that this is a productive avenue for further research. Natural health products may provide safe, effective, affordable, and easily accessible prevention of fetal brain injury and resulting lifelong disabilities.
导致脑瘫、发育障碍和精神健康障碍的大多数脑损伤都始于胎儿期。这些终身疾病给患者带来了巨大的经济和情感负担，因为它们几乎影响了患者生活各个领域的功能。不幸的是，目前的治疗选择有限。目前的重点仍然是在损伤发生后进行抢救、康复和再生，而不是旨在预防初始损伤。预防意味着在怀孕期间对母亲进行治疗，以改变胎儿的环境，并进而治疗胎儿。由于过去的错误，如沙利度胺的释放，人们仍然担心会伤害发育中的胎儿。在这篇综述中，我们概述了动物研究和临床试验的证据，这些研究探讨了母亲在围产期使用天然保健品（包括营养保健品和功能性食品）进行脑损伤预防的情况。具体来说，我们讨论了硫酸镁、肌酸、胆碱、褪黑素、白藜芦醇和西兰花芽/萝卜硫素。尽管只有硫酸镁的临床试验已经完成，但动物模型的结果很有希望，这表明这是进一步研究的一个有成效的途径。天然保健品可能为预防胎儿脑损伤和由此导致的终身残疾提供安全、有效、负担得起和易于获得的预防方法。
