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特纳综合征的心血管成像:全生命周期的前沿实践

Cardiovascular imaging in Turner syndrome: state-of-the-art practice across the lifespan.

作者信息

Mortensen Kristian H, Young Luciana, De Backer Julie, Silberbach Michael, Collins Ronnie Thomas, Duijnhouwer Anthonie L, Pandya Bejal, Gravholt Claus H, Lopez Leo, Roos-Hesselink Jolien W

机构信息

Cardiorespiratory Unit, Great Ormond Street Hospital For Children NHS Foundation Trust, London, UK.

Division of Cardiology, Seattle Children's Hospital, Seattle, Washington, USA.

出版信息

Heart. 2018 Nov;104(22):1823-1831. doi: 10.1136/heartjnl-2017-312658. Epub 2018 Sep 18.

Abstract

Cardiovascular imaging is essential to providing excellent clinical care for girls and women with Turner syndrome (TS). Congenital and acquired cardiovascular diseases are leading causes of the lifelong increased risk of premature death in TS. Non-invasive cardiovascular imaging is crucial for timely diagnosis and treatment planning, and a systematic and targeted imaging approach should combine echocardiography, cardiovascular magnetic resonance and, in select cases, cardiac CT. In recent decades, evidence has mounted for the need to perform cardiovascular imaging in all females with TS irrespective of karyotype and phenotype. This is due to the high incidence of outcome-determining lesions that often remain subclinical and occur in patterns specific to TS. This review provides an overview of state-of-the-art cardiovascular imaging practice in TS, by means of a review of the most recent literature, in the context of a recent consensus statement that has highlighted the role of cardiovascular diseases in these females.

摘要

心血管成像对于为患有特纳综合征(TS)的女孩和女性提供优质临床护理至关重要。先天性和后天性心血管疾病是导致TS患者终身过早死亡风险增加的主要原因。无创心血管成像对于及时诊断和治疗规划至关重要,系统且有针对性的成像方法应结合超声心动图、心血管磁共振成像,在某些情况下还应结合心脏CT。近几十年来,越来越多的证据表明,无论核型和表型如何,所有TS女性都需要进行心血管成像。这是因为决定预后的病变发生率很高,这些病变通常仍处于亚临床状态,且以TS特有的模式出现。本综述通过回顾最新文献,在最近一份强调心血管疾病在这些女性中的作用的共识声明的背景下,概述了TS中最先进的心血管成像实践。

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