Belpomme D, Le Rol A, Pappo F, Bernheim J, Dautzenberg B, Brechot J M, Chastang C, Guerin R A
Bull Cancer. 1986;73(5):627-33.
So far there is no good evidence that chemotherapy improves survival in non small cell lung cancer. Reports of randomized trials testing chemotherapy versus supportive treatment alone are very few. In recent years, more and more emphasis has been put on the quality of life for cancer patients. Subjective tests such as Anamnestic comparative self Assessment (A.C.S.A. test, Dr. Bernheim) were designed as well as objective ones, using different types of self evaluation. However very few studies have been focused on this aspect in patients with non small cell lung cancer. Therefore the G.E.T.C.B. (Groupe d'Etude et de Traitement des Cancers Bronchiques) decided to initiate a cooperative randomized trial (02 CB 84) in metastatic epidermoid and large cell bronchus carcinoma, in order to test the potential benefit from chemotherapy in these tumors and how it affects the quality of live. In this trial, C.O.P.A.C. combination (Cyclophosphamide, Vincristine, Cis-Platinum, Adriamycin and CCNU) is randomized versus no chemotherapy. The quality of life is assessed monthly on the one hand by a modified A.C.S.A. test performed by a physician and on the other hand by a question list given to the patient. This question list attempts to evaluate the impact of disease as a reference point. Finally protocol 02 CB 84 (activated in 05/84) may give information about the effect of chemotherapy on both survival and quality of life.
到目前为止，尚无充分证据表明化疗能提高非小细胞肺癌患者的生存率。关于对比化疗与单纯支持治疗的随机试验报告非常少。近年来，越来越强调癌症患者的生活质量。设计了诸如记忆性比较自我评估（A.C.S.A.测试，伯恩海姆医生）等主观测试以及使用不同类型自我评估的客观测试。然而，很少有研究关注非小细胞肺癌患者的这一方面。因此，支气管癌研究与治疗小组（G.E.T.C.B.）决定在转移性表皮样和大细胞支气管癌患者中开展一项合作随机试验（02 CB 84），以测试化疗对这些肿瘤的潜在益处以及化疗如何影响生活质量。在该试验中，将环磷酰胺、长春新碱、顺铂、阿霉素和洛莫司汀（C.O.P.A.C.）联合化疗方案与不进行化疗进行随机对照。生活质量一方面通过医生进行的改良A.C.S.A.测试每月评估一次，另一方面通过提供给患者的问题清单进行评估。该问题清单试图以疾病影响作为参考点进行评估。最后，02 CB 84方案（于1984年5月启动）可能会提供有关化疗对生存率和生活质量影响的信息。
