Bickford P C, Hoffer B J, Freedman R
Brain Res. 1986 Oct 22;385(2):405-10. doi: 10.1016/0006-8993(86)91092-9.
The ability of norepinephrine (NE) to modulate climbing fiber activation of complex spike discharge in cerebellar Purkinje neurons was compared in young (3-6 months) and aged (18-20 months) Fischer 344 rats. In young rats, NE selectively inhibits spontaneous activity while climbing fiber evoked activity remains intact or increased. NE also increases the probability of observing 4 bursts of full-sized action potentials rather than partially inactivated action potentials in the complex spike. In older rats, both of these modulatory actions of NE on climbing fiber complex spike activation are markedly diminished. These data support the concept that age-related reductions in catecholamine modulation of synaptic inputs may contribute to CNS dysfunction found in senescence.
在年轻（3 - 6个月）和老年（18 - 20个月）的Fischer 344大鼠中，比较了去甲肾上腺素（NE）调节小脑浦肯野神经元复合峰放电的攀爬纤维激活的能力。在年轻大鼠中，NE选择性抑制自发活动，而攀爬纤维诱发的活动保持完整或增加。NE还增加了在复合峰中观察到4次全尺寸动作电位爆发而不是部分失活动作电位的概率。在老年大鼠中，NE对攀爬纤维复合峰激活的这两种调节作用均明显减弱。这些数据支持这样的概念，即与年龄相关的儿茶酚胺对突触输入调节的减少可能导致衰老过程中发现的中枢神经系统功能障碍。
