去甲肾上腺素对小脑浦肯野细胞传入突触活动反应的调节作用。
Noradrenaline modulation of the responses of the cerebellar Purkinje cell to afferent synaptic activity.
作者信息
Freedman R, Hoffer B J, Puro D, Woodward D J
出版信息
Br J Pharmacol. 1976 Aug;57(4):603-5. doi: 10.1111/j.1476-5381.1976.tb10391.x.
Abstract
Noradrenaline, applied by microiontophoresis to rat cerebellar Purkinje neurones, selectively depressed spontaneous neuronal discharge. Simple spike and complex spike excitations, evoked by stimulation of the mossy and climbing fibres, were relatively preserved during the inhibition of spontaneous activity, and the number of full-sized action potentials in the complex spike increased. Inhibition mediated by the basket and stellate cells was augmented. Thus, relative to the change in spontaneous activity, noradrenaline increased the responsiveness of the Purkinje cell to afferent input.
摘要
通过微离子电泳法将去甲肾上腺素施加于大鼠小脑浦肯野神经元，可选择性地抑制神经元的自发放电。在抑制自发放电活动期间，由苔藓纤维和攀缘纤维刺激诱发的简单锋电位和复合锋电位兴奋相对得以保留，并且复合锋电位中全尺寸动作电位的数量增加。篮状细胞和星状细胞介导的抑制作用增强。因此，相对于自发放电活动的变化，去甲肾上腺素增加了浦肯野细胞对传入输入的反应性。
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