Gherardi R, Gaulard P, Prost C, Rocha D, Imbert M, Andre C, Rochant H, Farcet J P
Cancer. 1986 Dec 15;58(12):2710-6. doi: 10.1002/1097-0142(19861215)58:12<2710::aid-cncr2820581226>3.0.co;2-d.
In two patients a peripheral neuropathy was the presenting symptom of a noncutaneous peripheral T-cell lymphoma. In the first patient, the neuropathy had a relapsing and remitting course, the symptoms improved under corticosteroid therapy. The second patient suffered from a relentless neuropathy. In both cases the lymphoma infiltrated the peroneal nerve with an angiocentric and perivascular pattern resembling that observed in central nervous system lymphomas. The characterization of T-cell subsets in the lymph node showed cells with the helper/inducer and suppressor/cytotoxic phenotype in the first case and a predominance of cells with the helper/inducer phenotype in the second case. In the nerve, lymphocytes beard the helper/inducer phenotype antigen. A typical paraneoplastic vasculitis of nerve showed clearly different immunologic features.
在两名患者中，周围神经病变是一种非皮肤性外周T细胞淋巴瘤的首发症状。在首例患者中，神经病变呈复发缓解型病程，症状在皮质类固醇治疗下有所改善。第二例患者患有持续性神经病变。在这两例中，淋巴瘤均以血管中心性和血管周围性模式浸润腓总神经，类似于在中枢神经系统淋巴瘤中观察到的情况。淋巴结中T细胞亚群的特征显示，首例患者的细胞具有辅助/诱导和抑制/细胞毒性表型，第二例患者则以辅助/诱导表型细胞为主。在神经中，淋巴细胞带有辅助/诱导表型抗原。一种典型的副肿瘤性神经血管炎表现出明显不同的免疫学特征。
