de Graaf J, Minderhoud J M, Teelken A W
Clin Neurol Neurosurg. 1986;88(3):181-7. doi: 10.1016/s0303-8467(86)80026-9.
We report our results in profiling peripheral blood lymphocyte subpopulations with monoclonal antibodies in 17 multiple sclerosis (MS) patients, 22 patients with other neurological diseases (OND), and 11 healthy controls, using a blind experiment. Untreated patients with a chronic progressive MS have higher T-helper cell (OKT4+) counts and a higher ratio OKT4+/OKT8+ than other MS patients, OND or healthy controls. Two weeks after the onset of a relapse of MS there is a decreased T-helper and an increased T-suppressor cell percentage. Treatment with ACTH results in a significant increase of helper cells after 4 weeks of therapy. Patients with the lowest helper cell counts and the lowest helper/suppressor ratio show the best clinical improvement by ACTH. High OKT4+ cell percentages make a chronic progressive course of MS more probable.
我们采用盲法实验，报告了使用单克隆抗体对17例多发性硬化症（MS）患者、22例其他神经系统疾病（OND）患者和11名健康对照者外周血淋巴细胞亚群进行分析的结果。未经治疗的慢性进展型MS患者的辅助性T细胞（OKT4+）计数以及OKT4+/OKT8+比值高于其他MS患者、OND患者或健康对照者。MS复发发作两周后，辅助性T细胞减少，抑制性T细胞百分比增加。促肾上腺皮质激素（ACTH）治疗4周后，辅助性T细胞显著增加。辅助性T细胞计数和辅助性T细胞/抑制性T细胞比值最低的患者经ACTH治疗后临床改善最佳。OKT4+细胞百分比高使MS更有可能呈慢性进展病程。
