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Is APOE ε4 required for Alzheimer's disease to develop in TREM2 p.R47H variant carriers?

作者信息

Guerreiro R, Orme T, Naj A C, Kuzma A B, Schellenberg G D, Bras J

机构信息

UK Dementia Research Institute at UCL (UK DRI), London, UK.

Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.

出版信息

Neuropathol Appl Neurobiol. 2019 Feb;45(2):187-189. doi: 10.1111/nan.12517. Epub 2018 Oct 24.

Abstract
摘要

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APOE ε4 is also required in TREM2 R47H variant carriers for Alzheimer's disease to develop.
Neuropathol Appl Neurobiol. 2019 Feb;45(2):183-186. doi: 10.1111/nan.12474. Epub 2018 Mar 1.
3
The Alzheimer's Disease Sequencing Project: Study design and sample selection.
Neurol Genet. 2017 Oct 13;3(5):e194. doi: 10.1212/NXG.0000000000000194. eCollection 2017 Oct.
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