[Role of sympathetic vasoconstrictors in providing for the aerobic capacity of skeletal muscle].

The role of sympathetic vasoconstrictors in the mechanisms controlling the redistribution of blood flow to active muscle fibers in forearm muscles during and after handgrip with 10% MVC, was studied. Functional desympathization (blockade of the stellate ganglion and alpha 1-receptors with prazosin) led to shunting of active muscle fibers, subsequent activation of anaerobic glycolysis and decrease of aerobic working capacity. Increased concentration of lactate in the interstitial space of resting muscles causes analogous disturbances of blood flow redistribution and aerobic working capacity during contraction of these muscles.