Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Immunity. 2018 Sep 18;49(3):397-412. doi: 10.1016/j.immuni.2018.07.017.
Successful pregnancy requires carefully-coordinated communications between the mother and fetus. Immune cells and cytokine signaling pathways participate as mediators of these communications to promote healthy pregnancy. At the same time, certain infections or inflammatory conditions in pregnant mothers cause severe disease and have detrimental impacts on the developing fetus. In this review, we examine evidence for the role of maternal and fetal immune responses affecting pregnancy and fetal development, both under homeostasis and following infection. We discuss immune responses that are necessary to promote healthy pregnancy and those that lead to congenital disorders and pregnancy complications, with a particular emphasis on the role of interferons and cytokines. Understanding the contributions of the immune system in pregnancy and fetal development provides important insights into the pathogenesis underlying maternal and fetal diseases and sheds insights on possible targets for therapy.
成功的妊娠需要母亲和胎儿之间精心协调的沟通。免疫细胞和细胞因子信号通路作为这些通讯的介质参与其中，以促进健康的妊娠。与此同时，孕妇的某些感染或炎症状况会导致严重的疾病，并对发育中的胎儿产生不利影响。在这篇综述中，我们研究了母体和胎儿免疫反应在妊娠和胎儿发育中的作用的证据，包括在稳态和感染后。我们讨论了促进健康妊娠所必需的免疫反应，以及导致先天性疾病和妊娠并发症的免疫反应，特别强调了干扰素和细胞因子的作用。了解免疫系统在妊娠和胎儿发育中的作用为母体和胎儿疾病的发病机制提供了重要的见解，并为治疗提供了可能的靶点。
