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本文引用的文献

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Delayed currents in myelinated nerve fibres of Xenopus laevis investigated with voltage clamp technique.用电压钳技术研究非洲爪蟾有髓神经纤维中的延迟电流。
J Physiol. 1962 Jan;160(1):40-5. doi: 10.1113/jphysiol.1962.sp006832.
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Membrane currents in isolated frog nerve fibre under voltage clamp conditions.电压钳制条件下分离的蛙神经纤维中的膜电流。
J Physiol. 1958 Aug 29;143(1):76-90. doi: 10.1113/jphysiol.1958.sp006045.
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On the effects of strychnine upon the myelinated nerve fibres of toads.关于士的宁对蟾蜍有髓神经纤维的作用
Jpn J Physiol. 1956 Jun 15;6(2):175-89. doi: 10.2170/jjphysiol.6.175.
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Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons.乌贼轴突中季铵离子注入引起的钾离子电导失活及相关现象。
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The permeability of the sodium channel to organic cations in myelinated nerve.有髓神经中钠通道对有机阳离子的通透性。
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Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons.四乙铵离子衍生物与巨轴突钾通道的相互作用。
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Effects of strychnine on ionic conductances of squid axon membrane.士的宁对鱿鱼轴突膜离子电导的影响。
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Ionic blockage of sodium channels in nerve.神经中钠通道的离子阻断
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The inner quaternary ammonium ion receptor in potassium channels of the node of Ranvier.郎飞结钾通道中的内源性季铵离子受体。
J Gen Physiol. 1972 Apr;59(4):388-400. doi: 10.1085/jgp.59.4.388.
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士的宁对蛙类郎飞结钾离子电导的影响。

Effects of strychnine on the potassium conductance of the frog node of Ranvier.

作者信息

Shapiro B I

出版信息

J Gen Physiol. 1977 Jun;69(6):897-914. doi: 10.1085/jgp.69.6.897.

DOI:10.1085/jgp.69.6.897
PMID:302320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2215334/
Abstract

The nature of the block of potassium conductance by strychnine in frog node of Ranvier was investigated. The block is voltage-dependent and reaches a steady level with a relaxation time of 1 to several ms. Block is increased by depolarization or a reduction in [K+]O as well as by increasing strychnine concentration. A quaternary derivative of strychnine produces a similar block only when applied intracellularly. In general and in detail, strychnine block resembles that produced by intracellular application of the substituted tetraethylammonium compounds extensively studied by C.M. Armstrong (1969. J. Gen Physiol. 54:553-575. 1971. J. Gen. Physiol. 58:413-437). The kinetics, voltage dependence, and dependence on [K+]O of strychnine block are of the same form. It is concluded that tertiary strychnine must cross the axon membrane and block from the axoplasmic side in the same fashion as these quaternary amines.

摘要

研究了士的宁对青蛙郎飞结钾电导的阻断性质。这种阻断是电压依赖性的，在1到数毫秒的弛豫时间后达到稳定水平。去极化、降低细胞外[K⁺]浓度以及增加士的宁浓度都会增强阻断作用。士的宁的一种季铵衍生物只有在细胞内应用时才会产生类似的阻断作用。总体而言且具体来说，士的宁阻断类似于C.M.阿姆斯特朗（1969年，《普通生理学杂志》54:553 - 575；1971年，《普通生理学杂志》58:413 - 437）广泛研究的细胞内应用取代四乙铵化合物所产生的阻断。士的宁阻断的动力学、电压依赖性以及对细胞外[K⁺]的依赖性具有相同的形式。得出的结论是，叔胺型士的宁必定以与这些季铵胺相同的方式穿过轴突膜并从轴浆侧进行阻断。