Ozturk Arinc, Grajo Joseph R, Gee Michael S, Benjamin Alex, Zubajlo Rebecca E, Thomenius Kai E, Anthony Brian W, Samir Anthony E, Dhyani Manish
Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Division of Abdominal Imaging, Department of Radiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Ultrasound Med Biol. 2018 Dec;44(12):2461-2475. doi: 10.1016/j.ultrasmedbio.2018.07.019. Epub 2018 Sep 16.
Non-alcoholic fatty liver disease is a condition that is characterized by the presence of >5% fat in the liver and affects more than one billion people worldwide. If adequate and early precautions are not taken, non-alcoholic fatty liver disease can progress to cirrhosis and death. The current reference standard for detecting hepatic steatosis is a liver biopsy. However, because of the potential morbidity associated with liver biopsies, non-invasive imaging biomarkers have been extensively investigated. Magnetic resonance imaging-based methods have proven accuracy in quantifying liver steatosis; however, these techniques are costly and have limited availability. Ultrasound-based quantitative imaging techniques are increasingly utilized because of their widespread availability, ease of use and relative cost-effectiveness. Several ultrasound-based liver fat quantification techniques have been investigated, including techniques that measure changes in the acoustic properties of the liver caused by the presence of fat. In this review, we focus on quantitative ultrasound approaches and their diagnostic performance in the realm of non-alcoholic fatty liver disease.
非酒精性脂肪性肝病是一种以肝脏脂肪含量超过5%为特征的疾病，全球有超过10亿人受其影响。如果不采取充分的早期预防措施，非酒精性脂肪性肝病可能会发展为肝硬化并导致死亡。目前检测肝脂肪变性的参考标准是肝活检。然而，由于肝活检存在潜在的发病率，非侵入性成像生物标志物已得到广泛研究。基于磁共振成像的方法在量化肝脏脂肪变性方面已被证明具有准确性；然而，这些技术成本高昂且可用性有限。基于超声的定量成像技术因其广泛的可用性、易用性和相对成本效益而越来越多地被使用。已经研究了几种基于超声的肝脏脂肪定量技术，包括测量由脂肪存在引起的肝脏声学特性变化的技术。在这篇综述中，我们重点关注定量超声方法及其在非酒精性脂肪性肝病领域的诊断性能。
