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代谢功能障碍相关脂肪性肝病的新定义:超声和弹性成像的作用

The new definition of metabolic dysfunction-associated steatotic liver disease: the role of ultrasound and elastography.

作者信息

Jin Xinrui, Yip Terry Cheuk-Fung, Wong Grace Lai-Hung, Wong Vincent Wai-Sun, Lai Jimmy Che-To

机构信息

Department of Medicine and Therapeutics, Medical Data Analytics Center, The Chinese University of Hong Kong, Hong Kong, China.

State Key Laboratory of Digestive Disease, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

出版信息

Ultrasonography. 2025 May;44(3):189-201. doi: 10.14366/usg.24219. Epub 2025 Mar 18.

DOI:10.14366/usg.24219
PMID:40211108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12081130/
Abstract

In 2023, nonalcoholic fatty liver disease was renamed metabolic dysfunction-associated steatotic liver disease by the American and European liver associations. This new nomenclature recognizes metabolic dysfunction as the central driver of the disease, and the diagnostic criteria now require the presence of hepatic steatosis plus at least one of five cardiometabolic risk factors. B-mode ultrasonography remains the most common and practical method for detecting hepatic steatosis, although newer ultrasound techniques based on attenuation, backscatter, and speed of sound have gained traction as tools to diagnose and quantify hepatic steatosis. Additionally, ultrasound elastography is increasingly used in routine clinical practice to assess liver fibrosis, diagnose cirrhosis, and identify clinically significant portal hypertension.

摘要

2023年,美国和欧洲肝脏协会将非酒精性脂肪性肝病重新命名为代谢功能障碍相关脂肪性肝病。这一新命名法将代谢功能障碍视为该疾病的核心驱动因素,目前的诊断标准要求存在肝脂肪变性以及五个心血管代谢危险因素中的至少一个。B型超声检查仍然是检测肝脂肪变性最常用且实用的方法,尽管基于衰减、背向散射和声速的新型超声技术作为诊断和量化肝脂肪变性的工具已越来越受到关注。此外,超声弹性成像在常规临床实践中越来越多地用于评估肝纤维化、诊断肝硬化以及识别具有临床意义的门静脉高压。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe94/12081130/4107936e0e4c/usg-24219f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe94/12081130/0a04a0885d60/usg-24219f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe94/12081130/426922a5f34d/usg-24219f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe94/12081130/4107936e0e4c/usg-24219f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe94/12081130/0a04a0885d60/usg-24219f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe94/12081130/426922a5f34d/usg-24219f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe94/12081130/4107936e0e4c/usg-24219f3.jpg

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本文引用的文献

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Cardiometabolic criteria as predictors and treatment targets of liver-related events and cardiovascular events in metabolic dysfunction-associated steatotic liver disease.代谢相关脂肪性肝病中心血管代谢相关预测指标及治疗靶点与肝脏相关事件和心血管事件的关系。
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WFUMB Guidelines/Guidance on Liver Multiparametric Ultrasound. Part 2: Guidance on Liver Fat Quantification.WFUMB 肝脏多参数超声指南/指导。第 2 部分:肝脏脂肪定量指导。
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The Global Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among Patients With Type 2 Diabetes.2 型糖尿病患者中非酒精性脂肪性肝病和非酒精性脂肪性肝炎的全球流行病学。
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JAMA. 2024 Apr 16;331(15):1287-1297. doi: 10.1001/jama.2024.1447.
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Pol Arch Intern Med. 2024 Apr 26;134(4). doi: 10.20452/pamw.16703. Epub 2024 Mar 18.
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