免疫抑制小鼠中致死性播散性痘苗病毒感染的治疗
Treatment of fatal disseminated vaccinia virus infection in immunosuppressed mice.
作者信息
Worthington M, Conliffe M
出版信息
J Gen Virol. 1977 Aug;36(2):329-333. doi: 10.1099/0022-1317-36-2-329.
PMID:302323
Abstract
Studies were performed to compare the therapeutic effectiveness of three antiviral drugs (ARA-A, ARA-C and IDU) on the course of fatal disseminated vaccinia virus infection in immunosuppressed mice. Treatment with ARA-A begun as late as 7 days after virus infection was significantly effective in preventing death; no antiviral effect of the other two drugs was demonstrated.
摘要
进行了多项研究，以比较三种抗病毒药物（阿糖腺苷、阿糖胞苷和碘苷）对免疫抑制小鼠致命性播散性痘苗病毒感染病程的治疗效果。在病毒感染后7天开始用阿糖腺苷治疗，对预防死亡有显著效果；未显示其他两种药物有抗病毒作用。
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