雌性仓鼠2型单纯疱疹病毒生殖器感染的化疗
Chemotherapy of genital herpes simplex virus type 2 infections of female hamsters.
作者信息
Renis H E
出版信息
Antimicrob Agents Chemother. 1977 Apr;11(4):701-7. doi: 10.1128/AAC.11.4.701.
Abstract
The antiviral activity of 1-beta-d-arabinofuranosylcytosine (ara-C, cytarabine, Cytosar), 5-iodo-2'-deoxyuridine (IdUrd), 9-beta-d-arabinofuranosyladenine (ara-A), and disodium phosphonoacetate (PAA) have been compared in herpes simplex virus type 2 (HSV-2)-infected primary rabbit kidney cells and in female hamsters with genital HSV-2 infection. In vitro, ara-C and IdUrd were more active than ara-A, and PAA was least active. In female hamsters with genital HSV-2 infection, intravaginal treatment with PAA or ara-A was more effective than either ara-C or IdUrd. PAA was more active than ara-A when treatment was initiated early (1 h) after infection. The activity of PAA was greatly reduced if initiation of treatment was delayed for 24 h. Both PAA and ara-A reduced the virus titers of the vagina and protected hamsters from death when the drugs were given by either the intravaginal or subcutaneous route, with intravaginal treatment being more effective.
摘要
已在感染2型单纯疱疹病毒（HSV - 2）的原代兔肾细胞以及患有生殖器HSV - 2感染的雌性仓鼠中比较了1-β-D-阿拉伯呋喃糖基胞嘧啶（ara - C，阿糖胞苷，赛德萨）、5-碘-2'-脱氧尿苷（IdUrd）、9-β-D-阿拉伯呋喃糖基腺嘌呤（ara - A）和膦酰乙酸二钠（PAA）的抗病毒活性。在体外，ara - C和IdUrd比ara - A更具活性，而PAA活性最低。在患有生殖器HSV - 2感染的雌性仓鼠中，经阴道给予PAA或ara - A比给予ara - C或IdUrd更有效。感染后早期（1小时）开始治疗时，PAA比ara - A更具活性。如果治疗开始延迟24小时，PAA的活性会大大降低。当通过阴道内或皮下途径给药时，PAA和ara - A都能降低阴道中的病毒滴度，并保护仓鼠免于死亡，其中阴道内治疗更有效。
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